Application of High Performance Liquid Chromatography for the Measurements of Lipophilicity and Bio-mimetic Binding Properties in Drug Discovery
نویسنده
چکیده
2.2. THEORETICAL BACKGROUND OF HPLC ........................................................................................ 65 2.2.1. Direct measurement of lipophilicity by chromatographic methods ....................68 2.2.2. Measurements of lipophilicity using isocratic chromatographic retention ......70 2.2.3. Measurements of lipophilicity using gradient chromatographic retention ......73 2.2.4. pH dependence of lipophilicity and reversed phase chromatographic retention ..........................................................................................................................................74
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